基于RFID和指静脉识别的化学药品智能管理柜设计

为保障实验室中存放的药品安全, 提出一种基于射频识别(RFID)和指静脉识别的化学药品智能管理柜. 智能柜采用RFID、指静脉识别等物联网技术, 通过用户身份认证, 化学药品的自动识别、记录以及存储空间的智能控制, 实现实验室化学药品的高效安全管理. 样机实际测试结果表明, 系统可以较好地通过指静脉识别对使用者的身份进行认证, 也能够通过RFID快速识别化学药品; 系统智能化程度高, 各项功能完备, 可显著提高实验室化学药品管理能力.     

Afterglow Implant for Arterial Embolization and Intraoperative Imaging

Transcatheter arterial embolization (TAE) is wildly used in clinical treatments. However, the online monitoring of the thrombosis formation is limited due to the challenges of the direct visualization of embolic agents and the real-time monitoring of dynamic blood flow. Thus, we developed a photochemical afterglow implant with strong afterglow intensity and a long lifetime for embolization and imaging. The liquid pre-implant injected into the abdominal aorta of mice was rapidly transformed into a hydrogel in situ to embolize the blood vessel. The vascular embolism position can be observed by the enhanced afterglow of the fixed implant, and the long lifetime of afterglow can also be used to monitor the effect of embolization. This provides an excellent candidate in bio-imaging to avoid the autofluorescence interference from continuous light excitation. The study suggests the potential usefulness of the implant as an embolic agent in TAE and artery imaging during a surgical procedure.     

早期视网膜分支静脉阻塞患者倍频固体激光治疗对临床疗效及CMT值变化的影响

本文探讨了早期视网膜分支静脉阻塞患者倍频固体激光治疗对临床疗效及黄斑中心视网膜厚度(CMT)值变化的影响。将因视网膜分支静脉阻塞行激光治疗的30例患者纳入激光组,同期行常规治疗的30例患者纳入对照组,对比两组临床疗效、视力、CMT值变化、眼底荧光血管造影(FFA)检查渗透率及并发症。结果显示,治疗后激光组患者临床治疗总有效率、各个时间点视力变化、CMT值及FFA检查渗透发生率均优于对照组(P<0.05),两组患者均随访6个月,并发症比较差异无统计学意义(P>0.05)。说明早期视网膜分支静脉阻塞患者使用倍频固体激光治疗临床效果显著,可有效提高其视力水平,降低CMT值。     

A novel imaging tool for hepatic portal system using phase contrast technique with hydrogen peroxide‐generated O2 gas

The objective of this study was to investigate the potential of hydrogen peroxide‐generated oxygen gas‐based phase contrast imaging (PCI) for visualizing mouse hepatic portal veins. The O₂ gas was made from the reaction between H₂O₂ and catalase. The gas production was imaged by PCI in real time. The H₂O₂ was injected into the enteric cavity of the lower sigmoid colon to produce O₂ in the submucosal venous plexus. The generated O₂ gas could be finally drained into hepatic portal veins. Absorption contrast imaging (ACI) and PCI of O₂‐filled portal veins were performed and compared. PCI offers high resolution and real‐time visualization of the O₂ gas production. Compared with O₂‐based ACI, O₂‐based PCI significantly enhanced the revealing of the portal vein in vivo. It is concluded that O₂‐based PCI is a novel and promising imaging modality for future studies of portal venous disorders in mice models.     

变截面门式刚架结构分析的微分求积单元法

本文采用一种精确、简便的数值计算方法——微分求积单元法(DQEM)对变截面门式刚架结构进行了力学分析。首先建立了一般荷载作用下变截面构件的平衡微分方程，并采用微分求积法进行离散，进而得出了较为精确的分析变截面构件的单元力学模型。该模型的刚度方程不仅反映了单元的刚度性质，而且反映了单元的实际荷载作用，可较为精确地分析变截面门式刚架结构在分布载荷作用下的受力性能。通过与有限元法计算结果的比较，表明了微分求积单元法在变截面刚架的力学分析中的正确性和优越性。微分求积单元法可用于任意形状的刚架结构的静力分析。     

Lee极值原理与结构的大挠度塑性动力响应

本文介绍了利用Lee 极值原理确定结构的大挠度塑性动力响应的数值方法,给出了在均布冲击载荷作用下的理想刚塑性门形框架的大挠度进化模态解,指出如果模态形式取得合适,可使进化模态解接近于真实解.这样得到的门形框架的大挠度模态解与文献[8]中的实验结果和文献[9]中的大挠度完全解都符合得很好.     

Stimulation of Microvascular Networks on Sulfonated Polyrotaxane Surfaces with Immobilized Vascular Endothelial Growth Factor

Modulation of material properties and growth factor application are critical in constructing suitable cell culture environments to induce desired cellular functions. Sulfonated polyrotaxane (PRX) surfaces with immobilized vascular endothelial growth factors (VEGFs) are prepared to improve network formation in vascular endothelial cells. Sulfonated PRXs, whereby sulfonated α‐cyclodextrins (α‐CDs) are threaded onto a linear poly(ethylene glycol) chain capped with bulky groups at both terminals, are coated onto surfaces. The molecular mobility of sulfonated PRX surfaces is modulated by tuning the number of threading α‐CDs. VEGF is immobilized onto surfaces with varying mobility. Low mobility and VEGF‐immobilization reinforce cell proliferation, yes‐associated protein activity, and rhoA, pdgf, ang‐1, and pecam‐1 gene expression. Highly mobile surfaces and soluble VEGF weakly affect these cell responses. Network formation is strongly stimulated in vascular endothelial cells only on low‐mobility VEGF‐immobilized surfaces, suggesting that molecular mobility and VEGF immobilization synergistically control cell function.     

颈内静脉原位导丝法换置中心静脉长期血液透析导管的临床应用

目的探讨经颈内静脉原位导丝法换置中心静脉长期血液透析导管在维持性血液透析（MHD）患者中的应用价值。方法选取近3年在颈内静脉留置的中心静脉长期血液透析导管因功能障碍后，并经颈内静脉原位导丝法换置长期导管，术后及每次透析后均改用尿激酶封管患者16例（原位换置组）；选取同期首次经颈内静脉留置中心静脉长期血液透析导管,普通肝素封管患者20例作为对照组；分析两组患者围术期泵控血流量及随访期的反应及开存期率、次开存期率。结果围术期泵控血流量原位换置组高于对照组，有统计学差异（P＜0.05）；两组比较感染例次/1000导管日0.9%与1.0%，无统计学差异（P＞0.05）。原位换置组围术期未发生中重度并发症，12个月开存期率81.2%、次开存期率93.8%；对照组开存期率为65%、次开存期率85%；两组比较无统计学差异（P＞0.05）。结论颈内静脉原位导丝法换置中心静脉长期血液透析导管，在MHD患者中的使用是安全的、可行的。     

CTA在急性复杂性大咯血患者行介入栓塞术前的应用价值分析

本文探讨了CT血管造影(CT angiography,CTA)在急性复杂性大咯血患者行介入栓塞术前的应用价值。回顾性选择49例急性复杂性大咯血患者CTA影像资料,通过与术中数字减影血管造影(digital subtraction angiography,DSA)结果进行对比,发现CTA对罪犯血管诊断准确率为89.33%,对多动脉交通吻合诊断准确率为86.96%。Kappa检验CTA与DSA检查结果一致性较高,受试者特征曲线(ROC)分析CTA诊断急性复杂性大咯血罪犯血管的曲线下面积(AUC)为0.947(95%CI:0.903~0.990,P=0.000),灵敏度89.33%,特异度100.00%。通过随访发现CTA指导下行介入栓塞术治疗有效率91.84%,术后1年无大咯血复发病例。     

DSC examination of the esophagus after implantation of special stents,designed for the management of acute esophagus variceal bleeding

Massive bleeding from esophagus varices presents a life threatening complication of portal hypertension. No effective method of treatment is available until now, that would guarantee high grade of patient wellness during the conditioning and investigation phase until the definitive treatment could be introduced. The aim of this study was to evaluate the tissue response to esophagus stents - designed for manage acute variceal bleeding - in animal experiment. Self-expandable nitinol stents were introduced into the esophagus of six porcines. Another twelve porcines were undergone the same procedure, using the new biodegradable stents made of PDO (polydioxanon). Histological investigations of the stented esophagus segments were observed after 2 and 4 weeks at the first 12 animals. To monitor the time of stent degradation, histology were performed 7 and 12 weeks after the implantation in the biodegradable group (3–3 animals). Differential scanning calorimetric examination was performed in all esophagus samples. Focal erosion of the esophagus segments was more explicit in the nitinol group at the histology. On the 7^th week all of the biodegradable stent were in the stomach and on the 12^th week these were completely solved. DSC examination showed significant alterations in the structure of the esophagus in both stented group compared to the healthy control. This experiment showed that the new self-expandable stents are safety and suitable procedure without deterioration of the esophageal wall. According to our DSC results the thermal denaturation of intact esophagus, its mucosa and muscle fragments revealed significant differences compared to healthy sample in favour the new biodegradable stent. Safety and efficiency in the experimental model had encouraged us to apply this method successfully patients with bleeding esophagus varices. The long term goal is to show that stent placement could be an effective way of decreasing or stabilising the acute bleeding from ruptured esophagus varices in cirrhotic patients.